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A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum

Eric C.H. Lai,Kam Man Chung,Stephanie H.Y. Lau,Wan Yee Lau

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 108-111 doi: 10.1007/s11684-014-0344-0

Abstract:

Hemoperitoneum is a rare and potentially life-threatening complication of GIST.disseminated intra-abdominal recurrence from a previously resected gastrointestinal stromal tumour (GIST) of the small bowel, and the patient presented with hemoperitoneum.Resection of the ruptured GIST was carried out for control of bleeding and to prevent recurrent bleedingIn this patient who presented with spontaneous rupture of a small intestinal GIST, the novel use of targeted

Keywords： gastrointestinal stromal tumour     hemoperitoneum     small bowel GIST     small bowel neoplasm     imatinib    

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Severe adhesive small bowel obstruction

Salomone Di Saverio, Fausto Catena, Michael D. Kelly, Gregorio Tugnoli, Luca Ansaloni

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 436-439 doi: 10.1007/s11684-012-0221-7

Abstract:

Adhesive small bowel obstruction is a frequent cause of hospital admission.A 58-year-old patient was operated for extensive adhesive small bowel obstruction after having had twobowel obstruction.For patients admitted several times for adhesive small bowel obstruction, the relative risk of recurringSeveral strategies for non-operative conservative management of adhesive small bowel obstruction have

Keywords： post-operative intraperitoneal adhesions     adhesive small bowel obstruction     adhesiolysis     antiadhesion treatments    

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Gut microbiota and its implications in small bowel transplantation

Chenyang Wang, Qiurong Li, Jieshou Li

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 239-248 doi: 10.1007/s11684-018-0617-0

Abstract: In fact, several studies indicated that acute and chronic allograft rejection in small bowel transplantation

Keywords： gut microbiota     small bowel transplantation     acute rejection     chronic rejection     mucosal immunity     biomarker    

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Simulation and experimental improvement on a small-scale Stirling thermo-acoustic engine

Mao CHEN,Yonglin JU

Frontiers in Energy 2016, Volume 10, Issue 1,   Pages 37-45 doi: 10.1007/s11708-015-0390-6

Abstract: In this paper, the influence of the dimensions of the main parts of the small-scale Stirling thermo-acousticBased on the numerical simulation, a small-scale Stirling thermo-acoustic engine were constructed and

Keywords： thermo-acoustic Stirling engine     small-scale     simulation     experiment    

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Discovery of small molecule degraders for modulating cell cycle

Frontiers of Medicine   Pages 823-854 doi: 10.1007/s11684-023-1027-5

Abstract: The cell cycle is a complex process that involves DNA replication, protein expression, and cell division. Dysregulation of the cell cycle is associated with various diseases. Cyclin-dependent kinases (CDKs) and their corresponding cyclins are major proteins that regulate the cell cycle. In contrast to inhibition, a new approach called proteolysis-targeting chimeras (PROTACs) and molecular glues can eliminate both enzymatic and scaffold functions of CDKs and cyclins, achieving targeted degradation. The field of PROTACs and molecular glues has developed rapidly in recent years. In this article, we aim to summarize the latest developments of CDKs and cyclin protein degraders. The selectivity, application, validation and the current state of each CDK degrader will be overviewed. Additionally, possible methods are discussed for the development of degraders for CDK members that still lack them. Overall, this article provides a comprehensive summary of the latest advancements in CDK and cyclin protein degraders, which will be helpful for researchers working on this topic.

Keywords： PROTAC     molecular glue     degrader     cell cycle     CDK     cyclin    

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Fine-tuning cell organelle dynamics during mitosis by small GTPases

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 339-357 doi: 10.1007/s11684-022-0926-1

Abstract: Small GTPases belonging to the Ras superfamily regulate various cell organelles during division.Being the key regulators of membrane dynamics, the dysregulation of small GTPases is widely associatedRecent discoveries shed light on the molecular properties of small GTPases as sophisticated modulatorsThis review collects current knowledge on small GTPases in the regulation of cell organelles during mitosisand highlights the mediator role of small GTPase in transducing cell cycle signaling to organelle dynamics

Keywords： small GTPase     cell organelle     mitosis    

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Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis

Yue Yu, Jie He

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 157-171 doi: 10.1007/s11684-013-0272-4

Abstract:

Non-small-cell lung cancer (NSCLC) is the most common cause of premature death among the malignant

Keywords： non-small-cell lung cancer     molecular typing     individualized medicine     molecular-targeted therapy     gene expression    

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Performance prediction of switched reluctance generator with time average and small signal models

Jyoti KOUJALAGI, B. UMAMAHESWARI, R. ARUMUGAM

Frontiers in Energy 2013, Volume 7, Issue 1,   Pages 56-68 doi: 10.1007/s11708-012-0216-8

Abstract: mathematical model and predicts the performance of switched reluctance generator with time average and smallFinally, to track control voltage and current wave shapes, a small signal model is designed.

Keywords： generator     reluctance     switching model     small signal model     time average model    

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Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 18-42 doi: 10.1007/s11684-022-0976-4

Abstract: With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expanding

Keywords： non-small cell lung cancer     driver mutations     treatment strategy     resistant mechanism     immune-checkpoint    

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Paternal environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 176-184 doi: 10.1007/s11684-021-0885-y

Abstract: Recently, small noncoding RNAs (sncRNAs) in sperm have seemed crucial to this transmission due to their

Keywords： small noncoding RNAs     epigenetic inheritance     paternal intergenerational inherence     extracellular vesicles    

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Bevacizumab in combination with pemetrexed and platinum for elderly patients with advanced non-squamous non-small-cell

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 610-617 doi: 10.1007/s11684-021-0827-8

Abstract: Bevacizumab, an anti-VEGF monoclonal antibody, has significantly improved the clinical outcomes of patients with advanced non-squamous NSCLC (ns-NSCLC). However, the safety and efficacy of bevacizumab for elderly patients with advanced NSCLC require further investigation. Thus, 59 patients were included in the present retrospective study, 22 patients in the bevacizumab plus pemetrexed and platinum (B+PP) group, and 37 patients in the pemetrexed and platinum (PP) group. For the entire cohort of patients, the median OS was 33.3 months, and the 1-year and 2-year overall survival rates were 88.5% and 67.8%, respectively. The median OS and 1-year and 2-year OS rates were 20.5 months, 70.3% and 0%, respectively, in the B+PP group and 33.4 months, 97.0% and 89.4%, respectively, in the PP group (P <0.001). The incidence of grade≥3 adverse events was higher in the B+PP group than in the PP group (27.3% vs. 10.8%, respectively; P=0.204). Univariate and multivariate analyses suggested that the receipt of≥5 cycles of first-line chemotherapy was an independent favorable prognostic factor for OS, whereas the addition of bevacizumab was an unfavorable prognostic factor. With increased toxicities, the addition of bevacizumab to PP does not improve the overall survival of elderly patients with advanced ns-NSCLC.

Keywords： bevacizumab     elderly patient     advanced non-small-cell lung cancer     overall survival     toxicity    

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Genetic biosensors for small-molecule products: Design and applications in high-throughput screening

Qingzhuo Wang,Shuang-Yan Tang,Sheng Yang

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1,   Pages 15-26 doi: 10.1007/s11705-017-1629-z

Abstract: Overproduction of small-molecule chemicals using engineered microbial cells has greatly reduced the productionFor this purpose, many genetic components have been adapted into biosensors of small molecules, whichcouple the intracellular concentrations of small molecules to easily detectable readouts such as fluorescenceSuch biosensors allow a high-throughput screening of the small-molecule products, and can be roughlyThis review summarizes the recent developments in the design and applications of biosensors for small-molecule

Keywords： biosensor     small molecule product     transcription factor     riboswitch     high-throughput screening    

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Lobectomy by video-assisted thoracoscopic surgery (VATS) for early stage of non-small cell lung cancer

Min ZHU, Xiang-Ning FU, Xiao-Ping CHEN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 53-60 doi: 10.1007/s11684-011-0121-2

Abstract: paper, we review the development of thoracoscopy, the present status of VATS for early stage of non-small

Keywords： non-small cell lung cancer     video-assisted thoracoscopic surgery     lobectomy    

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Accurate quantification of 3′-terminal 2′-O-methylated small RNAs by utilizing oxidative deep sequencing

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 240-250 doi: 10.1007/s11684-021-0909-7

Abstract: In particular, a subset of small RNAs, including microRNAs (miRNAs) and Piwi-interacting RNAs (piRNAsHowever, quantifying the levels of these small RNAs is difficult because 2′-O-methylation at the RNAAccurate measurement of the 3′-terminal 2′-O-methylation of small RNAs has profound implications for

Keywords： small RNAs     2′-O-methylation     sequencing     RT-qPCR    

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Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging

Xiaohuan Wang, Peng Zou, Fan Wu, Lu Lu, Shibo Jiang

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 449-461 doi: 10.1007/s11684-017-0589-5

Abstract: In this review, we summarize and discuss the latest progress in the development of small-molecule viralWe also discuss some general strategies for developing small-molecule viral inhibitors.

Keywords： emerging and re-emerging viruses     small-molecule inhibitor     coronavirus     Ebola virus     Zika virus     life cycle    

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Title Author Date Type Operation

A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum

Eric C.H. Lai,Kam Man Chung,Stephanie H.Y. Lau,Wan Yee Lau

Journal Article

Severe adhesive small bowel obstruction

Salomone Di Saverio, Fausto Catena, Michael D. Kelly, Gregorio Tugnoli, Luca Ansaloni

Journal Article

Gut microbiota and its implications in small bowel transplantation

Chenyang Wang, Qiurong Li, Jieshou Li

Journal Article

Simulation and experimental improvement on a small-scale Stirling thermo-acoustic engine

Mao CHEN,Yonglin JU

Journal Article

Discovery of small molecule degraders for modulating cell cycle

Journal Article

Fine-tuning cell organelle dynamics during mitosis by small GTPases

Journal Article

Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis

Yue Yu, Jie He

Journal Article

Performance prediction of switched reluctance generator with time average and small signal models

Jyoti KOUJALAGI, B. UMAMAHESWARI, R. ARUMUGAM

Journal Article

Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Journal Article

Paternal environmental exposure-induced spermatozoal small noncoding RNA alteration meditates the intergenerational

Journal Article

Bevacizumab in combination with pemetrexed and platinum for elderly patients with advanced non-squamous non-small-cell

Journal Article

Genetic biosensors for small-molecule products: Design and applications in high-throughput screening

Qingzhuo Wang,Shuang-Yan Tang,Sheng Yang

Journal Article

Lobectomy by video-assisted thoracoscopic surgery (VATS) for early stage of non-small cell lung cancer

Min ZHU, Xiang-Ning FU, Xiao-Ping CHEN

Journal Article

Accurate quantification of 3′-terminal 2′-O-methylated small RNAs by utilizing oxidative deep sequencing

Journal Article

Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging

Xiaohuan Wang, Peng Zou, Fan Wu, Lu Lu, Shibo Jiang

Journal Article